{"id":24526,"date":"2019-04-08T03:07:54","date_gmt":"2019-04-08T03:07:54","guid":{"rendered":"https:\/\/scoliolife.com\/stage\/?p=24526"},"modified":"2019-06-02T03:01:23","modified_gmt":"2019-06-02T03:01:23","slug":"%ec%b9%bc%ec%8a%98%ea%b3%bc-%eb%b9%84%ed%83%80%eb%af%bc-d-%eb%b3%b4%ec%b6%a9%ec%a0%9c%eb%a5%bc-%ec%b2%ad%ec%86%8c%eb%85%84%ea%b8%b0%ec%9d%98-%ed%8a%b9%eb%b0%9c%ec%84%b1-%ec%b2%99%ec%b6%94%ec%b8%a1","status":"publish","type":"post","link":"https:\/\/scoliolife.com\/stage\/%ec%b9%bc%ec%8a%98%ea%b3%bc-%eb%b9%84%ed%83%80%eb%af%bc-d-%eb%b3%b4%ec%b6%a9%ec%a0%9c%eb%a5%bc-%ec%b2%ad%ec%86%8c%eb%85%84%ea%b8%b0%ec%9d%98-%ed%8a%b9%eb%b0%9c%ec%84%b1-%ec%b2%99%ec%b6%94%ec%b8%a1\/","title":{"rendered":"\uce7c\uc298\uacfc \ube44\ud0c0\ubbfc D \ubcf4\ucda9\uc81c\ub97c \uccad\uc18c\ub144\uae30\uc758 \ud2b9\ubc1c\uc131 \ucc99\ucd94\uce21\ub9cc\uc99d\uc5d0 \uc0ac\uc6a9\ud558\ub294 \ud6a8\uc728\uc801\uc778 \uce58\ub8cc\uc801 \ud1b5\uc81c \u2013 \uc704\uc57d \ud6a8\uacfc \ud1b5\uc81c\ub97c \ud1b5\ud55c \uc784\uc758\uc801 \uc774\uc911\ub9f9\uac80\ubc95 \uc2dc\ud5d8"},"content":{"rendered":"<p>Bone Abstracts (2017) 6 OC8 | DOI: 10.1530\/boneabs.6.OC8<\/p>\n<p>\ubaa9\ud45c: \uccad\uc18c\ub144\uae30\uc758 \ud2b9\ubc1c\uc131 \ucc99\ucd94\uce21\ub9cc\uc99d(AIS)\uc740 \ub0ae\uc740 \uace8\uc9c8\ub7c9\uacfc \uc5f0\uad00\ub418\uc5b4 \uc788\uc2b5\ub2c8\ub2e4. \uc774 \uc5f0\uad6c\ub294 \ubf08\uc758 \uac15\ub3c4\ub97c \uac1c\uc120\ud558\uace0 AIS\uc758 \ub9cc\uace1\ub3c4 \uc545\ud654\ub97c \uc608\ubc29\ud558\ub294 \ub370\uc5d0 \uc788\uc5b4 \uce7c\uc298 \ubc0f \ube44\ud0c0\ubbfc D \ubcf4\ucda9\uc81c\uc758 \uce58\ub8cc\uc801 \ud6a8\uacfc \ubc0f \uadf8 \uacb0\uc815 \uc694\uc778\uc744 \ud3c9\uac00\ud558\ub294 \ub370\uc5d0 \ubaa9\uc801\uc744 \ub461\ub2c8\ub2e4.<\/p>\n<p>\ubc29\ubc95: \ubcf8 \uc2e4\ud5d8\uc740 \uc704\uc57d \ud6a8\uacfc \ud1b5\uc81c\ub97c \ud1b5\ud55c \uc784\uc758\uc801 \uc774\uc911\ub9f9\uac80\ubc95\uc744 \uc2dc\ud589\ud55c \uac83\uc73c\ub85c AIS \uc18c\ub140\ub4e4\uc744 \ubaa8\uc9d1\ud558\uc5ec \uc9c4\ud589\ub418\uc5c8\uc2b5\ub2c8\ub2e4 (\ub300\ud1f4 \uacbd\ubd80 BMDZ-\uc810\uc218<0 \ubc0f \ucf54\ube0c \uac01\ub3c4(Cobb angle)\u226515\u00b0\uc778 \ub9cc 11\u201314 \uc138, \ud0dc\ub108 \uc2a4\ud14c\uc774\uc9c0(Tanner stage)<IV). 330 \uba85\uc758 \ud53c\uc2e4\ud5d8\uc790\ub4e4\uc740 \uc784\uc758\uc801\uc73c\ub85c \ucd94\ucd9c\ub418\uc5b4 \uadf8\ub8f9 1(\uc704\uc57d), \uadf8\ub8f9 2(\ub9e4\uc77c 600mg\uce7c\uc298+400IU\ube44\ud0c0\ubbfcD3), \uadf8\ub8f9 3(\ub9e4\uc77c 600mg \uce7c\uc298+800IU\ube44\ud0c0\ubbfc D3)\uc73c\ub85c \ubc30\uc815\ub418\uc5b4 2\ub144 \uac04\uc758 \uce58\ub8cc\ub97c \ubc1b\uc558\uc2b5\ub2c8\ub2e4. \uc2dc\uc791 \uc2dc\uc810\uacfc 2\ub144 \uac04\uc758 \uc870\uc0ac\uc5d0\ub294 \ub2e4\uc74c\uc774 \ud3ec\ud568\ub429\ub2c8\ub2e4: (1) \uc694\uace8\uc694\uc6d0\ubd80 \uc0c1\uc758 HR-pQCT\uc5d0 \ub300\ud55c \uc720\ud55c \uc694\uc18c \ubd84\uc11d(FEA), (2)\ud608\uccad 25(OH)\ube44\ud0c0\ubbfc D \ubd84\uc11d, (3) \uc2dd\ub2e8\uc744 \ud1b5\ud55c \uce7c\uc298 \uc12d\ucde8. \ucf54\ube0c \uac01\ub3c4 \uc99d\uac00\u22656\u00b0\uc73c\ub85c \uc815\uc758\ub41c \ub9cc\uace1\ub3c4 \uc545\ud654\uc5d0 \ub300\ud574\uc11c\ub294 \ucd5c\uc2e0\uc758 \ud6c4\uc18d \ubd84\uc11d\uc774 \uc218\ud589\ub418\uc5c8\uc73c\uba70, \uc774\uc5d0 \ub300\ud574 SRS \uac00\uc774\ub4dc\ub77c\uc778\uc774 \uc900\uc218\ub418\uc5c8\uc2b5\ub2c8\ub2e4. P \uac12<0.05\uc774 \ud1b5\uacc4\uc801\uc73c\ub85c \uc720\uc758\ubbf8\ud55c \uac83\uc73c\ub85c \uace0\ub824\ub418\uc5c8\uc2b5\ub2c8\ub2e4.\n\n\uacb0\uacfc: 270 (81.8%) \uba85\uc758 \ud53c\uc2e4\ud5d8\uc790\ub4e4\uc774 \uc5f0\uad6c\ub97c \uc644\ub8cc\ud558\uc600\uc2b5\ub2c8\ub2e4. 2\ub144\uc774 \ub418\ub294 \uc2dc\uc810\uc5d0\uc11c, FEA \uc694\uc18c \uc0c1\uc758 \uc99d\uac00\ub294 \uce58\ub8cc \uadf8\ub8f9\uc5d0\uc11c \uc720\uc758\ubbf8\ud558\uac8c \ucef8\uc2b5\ub2c8\ub2e4 (\ud45c1).\n\n\ucd5c\uc2e0 \ud6c4\uc18d \uc5f0\uad6c\uc5d0\uc11c(N=132), \uadf8\ub8f9 3\uc758 21\u00b77%\uc640 \uadf8\ub8f9 2\uc75824\u00b74% \uac00 \uc545\ud654\ub41c \ub370 \ube44\ud574 \uadf8\ub8f9 1\uc5d0\uc11c\ub29446\u00b77%\uac00 \uc545\ud654\ub418\uc5c8\uc2b5\ub2c8\ub2e4(P=0.012, 0.032). \uadf8\ub8f9 \ub0b4 \ub85c\uc9c0\uc2a4\ud2f1 \ud68c\uadc0\ubd84\uc11d\uc744 \uadf8\ub8f9 3\uc5d0\uc11c \uc218\ud589\ud55c \uacb0\uacfc, \ud30c\uad34 \ud558\uc911\uc758 FEA \ubcc0\uc218\uc640 \uac89\ubcf4\uae30 \ud0c4\uc131 \uacc4\uc218\uc758 \uc99d\uac00\uac00 \ub9cc\uace1\ub3c4 \uc545\ud654\uc5d0 \ub300\ud55c \uc720\uc758\ubbf8\ud55c \uc608\ubc29\uc801\uc778 \uc694\uc18c\uac00 \ub418\uc5c8\uc2b5\ub2c8\ub2e4(\uac01\uac01 P=0.043 &#038; 0.034).\n\n\uc2dc\uc791 \uc2dc\uc810\uc5d0 \ud608\uccad 25(OH)\ube44\ud0c0\ubbfc D\u226450 nmol\/l\uc600\ub358 \uc774\ub4e4\uc740 (N=103), \uadf8\ub8f9 3\uc5d0\uc11c 16.2%\uac00 \uc545\ud654\ub41c \ub370\uc5d0 \ubc18\ud574, \uadf8\ub8f9 1\uc5d0\uc11c 48.6%\uac00 \uc545\ud654\ub418\uc5c8\uc2b5\ub2c8\ub2e4(P=0.003). 25(OH)\ube44\ud0c0\ubbfc D>50 nmol\/l\uc600\ub358 \uc774\ub4e4\uc740 (N=29), \uc8fc\ubaa9\ud560 \ub9cc\ud55c \ub9cc\uace1\ub3c4 \uc545\ud654 \uc0c1\uc758 \ucc28\uc774\uac00 \uc874\uc7ac\ud558\uc9c0 \uc54a\uc558\uc2b5\ub2c8\ub2e4. \uc2dc\uc791 \uc2dc\uc810\uc5d0 \uc601\uc591 \uc0c1\uc758 \uce7c\uc298 \uc12d\ucde8\u22641000 mg\/day\uc600\ub358 \uc774\ub4e4\uc740 (N=109), \uadf8\ub8f9 3\uc5d0\uc11c 19.0%\uac00 \uc545\ud654\ub41c \ub370\uc5d0 \ube44\ud574 \uadf8\ub8f9 1\uc5d0\uc11c\ub294 54.3%\uac00 \uc545\ud654\ub418\uc5c8\uc2b5\ub2c8\ub2e4(P=0.001). \uce7c\uc298 \uc12d\ucde8>1000 mg\/day \uc600\ub358 \uc774\ub4e4\uc740(N=23), \ub9cc\uace1\ub3c4 \uc545\ud654 \uc0c1\uc758 \uc8fc\ubaa9\ud560 \ub9cc\ud55c \ucc28\uc774\uac00 \uc874\uc7ac\ud558\uc9c0 \uc54a\uc558\uc2b5\ub2c8\ub2e4.<\/p>\n<p>\ud45c 1 Mean changes on \ud608\uccad 25(OH) \ube44\ud0c0\ubbfcD \uc218\uc900\uacfc \uadf8\ub8f9 1, 2, 3\uc5d0\uc11c\uc758 2\ub144 \ud6c4 \uc720\ud55c \uc694\uc18c \ubd84\uc11d(FEA) \ubcc0\uc218\u00a7.<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/scoliolife.com\/stage\/wp-content\/uploads\/2019\/04\/Table-Calcium-KO.jpg\" alt=\"\" width=\"609\" height=\"431\" class=\"alignright size-full wp-image-24527\" srcset=\"https:\/\/scoliolife.com\/stage\/wp-content\/uploads\/2019\/04\/Table-Calcium-KO.jpg 609w, https:\/\/scoliolife.com\/stage\/wp-content\/uploads\/2019\/04\/Table-Calcium-KO-600x425.jpg 600w, https:\/\/scoliolife.com\/stage\/wp-content\/uploads\/2019\/04\/Table-Calcium-KO-300x212.jpg 300w\" sizes=\"(max-width: 609px) 100vw, 609px\" \/><\/p>\n<p><strong>\uacb0\ub860: \ubcf8 \uc5f0\uad6c\uc758 \uacb0\uacfc\ub294 \uce7c\uc298+\ube44\ud0c0\ubbfcD\ubcf4\ucda9\uc774 AIS \uc0c1\uc758 \ubf08\uc758 \uac15\ub3c4\ub97c \uac1c\uc120\uc2dc\ucf1c\uc904 \uc218 \uc788\uc74c\uc5d0 \ub300\ud55c \uac15\ub825\ud55c \uc99d\uac70\ub97c \uc81c\uacf5\ud569\ub2c8\ub2e4. \ub9cc\uace1 \uc545\ud654\ub97c \uc608\ubc29\ud558\ub294 \uce58\ub8cc\uc801 \ud6a8\uacfc\ub294 FEA \ubcc0\uc218 \uc0c1\uc758 \uc99d\uac00,\uc2dc\uc791 \uc2dc\uc810\uc758 \ub0ae\uc74025(OH)\ube44\ud0c0\ubbfcD \uc218\uce58\uc640 \ub0ae\uc740 \uc2dc\uc791 \uc9c0\uc810\uc758 \uc601\uc591 \uc0c1\uc758 \uce7c\uc298 \uc12d\ucde8\uc640\uc0c1\uad00 \uad00\uacc4\ub97c \uac00\uc9d1\ub2c8\ub2e4.<\/strong><\/p>\n<p>\uc790\uae08 \uc9c0\uc6d0\ucc98Pfizer Inc (IIR\ud5c8\uac00:WI174540). (ClinicalTrials.gov-\uc2dd\ubcc4\ucf54\ub4dc: NCT01103115).<\/p>\n<p>\uacf5\uc2dc: \uc800\uc790\ub4e4\uc740 \uc5b4\ub5a0\ud55c \uc774\ud574 \uad00\uacc4\ub3c4 \uac16\uc9c0 \uc54a\uc2b5\ub2c8\ub2e4.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Bone Abstracts (2017) 6 OC8 | DOI: 10.1530\/boneabs.6.OC8 \ubaa9\ud45c: \uccad\uc18c\ub144\uae30\uc758 \ud2b9\ubc1c\uc131 \ucc99\ucd94\uce21\ub9cc\uc99d(AIS)\uc740 \ub0ae\uc740 \uace8\uc9c8\ub7c9\uacfc \uc5f0\uad00\ub418\uc5b4 \uc788\uc2b5\ub2c8\ub2e4. \uc774 \uc5f0\uad6c\ub294 \ubf08\uc758 \uac15\ub3c4\ub97c \uac1c\uc120\ud558\uace0 AIS\uc758 \ub9cc\uace1\ub3c4 \uc545\ud654\ub97c \uc608\ubc29\ud558\ub294 \ub370\uc5d0 \uc788\uc5b4 \uce7c\uc298 \ubc0f \ube44\ud0c0\ubbfc D \ubcf4\ucda9\uc81c\uc758 \uce58\ub8cc\uc801 \ud6a8\uacfc \ubc0f \uadf8 \uacb0\uc815 \uc694\uc778\uc744 \ud3c9\uac00\ud558\ub294 \ub370\uc5d0 \ubaa9\uc801\uc744 \ub461\ub2c8\ub2e4. \ubc29\ubc95: \ubcf8 \uc2e4\ud5d8\uc740 \uc704\uc57d \ud6a8\uacfc \ud1b5\uc81c\ub97c \ud1b5\ud55c \uc784\uc758\uc801 \uc774\uc911\ub9f9\uac80\ubc95\uc744 \uc2dc\ud589\ud55c \uac83\uc73c\ub85c AIS \uc18c\ub140\ub4e4\uc744 [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[14],"tags":[],"_links":{"self":[{"href":"https:\/\/scoliolife.com\/stage\/wp-json\/wp\/v2\/posts\/24526"}],"collection":[{"href":"https:\/\/scoliolife.com\/stage\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/scoliolife.com\/stage\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/scoliolife.com\/stage\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/scoliolife.com\/stage\/wp-json\/wp\/v2\/comments?post=24526"}],"version-history":[{"count":0,"href":"https:\/\/scoliolife.com\/stage\/wp-json\/wp\/v2\/posts\/24526\/revisions"}],"wp:attachment":[{"href":"https:\/\/scoliolife.com\/stage\/wp-json\/wp\/v2\/media?parent=24526"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/scoliolife.com\/stage\/wp-json\/wp\/v2\/categories?post=24526"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/scoliolife.com\/stage\/wp-json\/wp\/v2\/tags?post=24526"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}